The second major release of OnSIDES (On-label SIDE effectS resource) is now available at nsides.io and github.com/tatonetti-lab/onsides. This version contains significant model improvements and a simpler data structure. The result is significantly improved performance metrics (F1=90, AUROC=92, AUPR=95) at extracting adverse reactions from the FDA structured product labels. Thanks to all the TLab members that contributed to this release, including Cindy, Dhvani, Pietro, and Jason!