Network analysis framework that identifies adverse event (AE) neighborhoods within the human interactome (protein-protein interaction network). Drugs targeting proteins within this neighborhood are predicted to be involved in mediating the AE. Links drugs to seed sets of proteins and phenotypes, like drug side-effects and diseases. A description of the algorithm is available here. Code in Python available […]

Offsides and Twosides

Drug side effects and drug-drug interactions were mined from publicly available data. Offsides is a database of drug side-effects that were found, but are not listed on the official FDA label. Twosides is the only comprehensive database drug-drug-effect relationships. Over 1,000 drugs and 63,000 combinations connected to millions of potential adverse reactions. Download the data from […]