SINaTRA

Interspecies, network-based predictions of synthetic lethality and the first genome-wide scale prediction of synthetic lethality in humans. Scores were validated against three independent databases of synthetic lethal pairs in humans, mouse, and yeast. The original release contains ~109 million gene pairs with their associated synthetic lethality scores.

Human synthetic lethal gene pairs available in 3 parts: part 1, part 2, and part 3. And mouse too.