Featured Publications

Tissue-Specific Analysis of Pharmacological Pathways CPT: Pharmacometrics & Systems Pharmacology June 2018
Yun Hao, Kayla Quinnies, Ronald Realubit, Charles Karan, Nicholas P. Tatonetti
Disease Heritability Inferred from Familial Relationships Reported in Medical Records Cell May 2018
Fernanda C.G. Polubriaginof, Rami Vanguri, Kayla Quinnies, Gillian M. Belbin, Alexandre Yahi, Hojjat Salmasian, Tal Lorberbaum, Victor Nwankwo, Li Li, Mark M. Shervey, Patricia Glowe, Iuliana Ionita-Laza, Mary Simmerling, George Hripcsak, Suzanne Bakken, David Goldstein, Krzysztof Kiryluk, Eimear E. Kenny, Joel Dudley, David K. Vawdrey, Nicholas P. Tatonetti
"The team was pleased to find that height, obesity, diabetes, acne and sickle cell anemia all came out within a few percentage points of more traditional research studies. The data set also offered potential heritability data for about 400 items that had not previously been examined this way, including sinus infections, tooth decay, irregular menstruation and thyroid disorders."
'Will You Be My Emergency Contact?' Takes On a Whole New Meaning May 17, 2018, Continue Reading
"Hoping to explore the genetics of drug reactions, graduate student Fernanda Polubriaginof and others working in the lab of biomedical informatics researcher Nicholas Tatonetti at Columbia University wanted to determine whether patients at the school’s affiliated NewYork-Presbyterian Hospital were related."
Family trees hidden in medical records could predict your disease risk, May 17, 2018, Continue Reading
"Going to the hospital means filling out forms, and somewhere on that form is a place to list an emergency contact, with name, address, phone number, and relationship — just in case. A study published Thursday in Cell found a novel use for that information."
Researchers mine emergency contacts to discover genetic clues to disease, May 17, 2018, Continue Reading
"Because many people use relatives as their contact person and that contact might list another relative or next-of-kin information on their own forms, researchers from Columbia University and elsewhere were able to generate 223,000 family trees connecting blood relatives using electronic health record data from 3.5 million patients at three medical centers in New York."
Family Ties, May 17, 2018, Continue Reading
Estimate of disease heritability using 7.4 million familial relationships inferred from electronic health records bioRxiv Pre-print
Fernanda Polubriaginof, Rami Vanguri, Kayla Quinnies, Gillian Belbin, Alexandre Yahi, Hojjat Salmasian, Tal Lorberbaum, Victor Nwankwo, Li Li, Mark Shervey, Patricia Glowe, Iuliana Ionita-Laza, Mary Simmerling, George Hripcsak, Suzanne Bakken, David Goldstein, Krzysztof Kiryluk, Eimear Kenny, Joel Dudley, David K Vawdrey, Nicholas P Tatonetti
The Next Generation of Drug Safety Science: Coupling Detection, Corroboration, and Validation to Discover Novel Drug Effects and Drug-drug Interactions Clinical Pharmacology & Therapeutics January 2018
Nicholas P Tatonetti
Generative Adversarial Networks for Electronic Health Records: A Framework for Exploring and Evaluating Methods for Predicting Drug-Induced Laboratory Test Trajectories 31st Conference on Neural Information Processing Systems (NIPS 2017) December 2017
Alexandre Yahi, Rami Vanguri, Noemie Elhadad, Nicholas P Tatonetti
Machine learning: novel bioinformatics approaches for combating antimicrobial resistance Current opinion in infectious diseases December 2017
Nenad Macesic, Fernanda Polubriaginof, Nicholas P Tatonetti
Procedure prediction from symbolic electronic health records via time intervals analytics Journal of biomedical informatics November 2017
Robert Moskovitch, Fernanda Polubriaginof, Aviram Weiss, Patrick Ryan, Nicholas Tatonetti
Translational medicine in the Age of Big Data Briefings in bioinformatics October 2017
Nicholas P Tatonetti
Development of A Machine Learning Algorithm to Classify Drugs Of Unknown Fetal Effect Scientific reports October 2017
Mary Regina Boland, Fernanda Polubriaginof, Nicholas P Tatonetti
Uncovering exposures responsible for birth season-disease effects: a global study Journal of the American Medical Informatics Association September 2017
Mary Regina Boland, Pradipta Parhi, Li Li, Riccardo Miotto, Robert Carroll, Usman Iqbal, Phung-Anh Alex Nguyen, Martijn Schuemie, Seng Chan You, Donahue Smith, Sean Mooney, Patrick Ryan, Yu-Chuan Jack Li, Rae Woong Park, Josh Denny, Joel T Dudley, George Hripcsak, Pierre Gentine, Nicholas P Tatonetti
Climate classification is an important factor in assessing quality-of-care across hospitals Scientific Reports July 2017
Mary Regina Boland, Pradipta Parhi, Pierre Gentine, Nicholas P Tatonetti
Prognosis of clinical outcomes with temporal patterns and experiences with one class feature selection IEEE/ACM transactions on computational biology and bioinformatics May 2017
Robert Moskovitch, Hyunmi Choi, George Hripcsak, Nicholas P Tatonetti
Ten Simple Rules to Enable Multi-site Collaborations through Data Sharing PLOS Computational Biology January 2017
Mary Regina Boland, Konrad J Karczewski, Nicholas P Tatonetti
Pharmacological Factors Associated With Congestive Heart Failure Hospital Readmission: A Case-Study Using 15,768 Heart Failure Patients From Two Health Systems Circulation November 2016
Kipp W Johnson, Khader Shameer, Alexandre Yahi, Riccardo Miotto, Doran Ricks, Jebakumar Jebakaran, Patricia Kovatch, Partho Sengupta, David L Reich, Andrew Kasarskis, Sean Pinney, Nicholas Tatonetti, Joel T Dudley
Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation Journal of the American College of Cardiology October 2016
Tal Lorberbaum, Kevin J. Sampson, Jeremy B. Chang, Vivek Iyer, Raymond L. Woosley, Robert S. Kass, Nicholas P. Tatonetti
"By examining big data in entirely new ways, the team uncovered several drug combinations associated with increased risk of a potentially fatal heart arrhythmia. One pair included the popular antibiotic ceftriaxone and the heartburn medication lansoprazole, a former blockbuster drug best known by the brand name Prevacid."
Scientists see progress in identifying deadly drug interactions, October 10, 2016, Continue Reading
"Millions of Americans take more than one prescription drug, and often times doctors don't know which drugs, when combined, can cause serious illness or death. Sadly, such warnings come only after the damage is done, when enough clear reports of adverse reactions begin to emerge. Now, scientists at Columbia University in New York have harnessed the power of data science to identify two common prescription drugs that, if mixed, can have deadly consequences."
Deadly Mixture: Scientists Uncover Harmful Drug Interactions, October 10, 2016, Continue Reading
"The research, which used a combination of adverse event data-mining, electronic health record analysis and laboratory experiments, found that patients who received both drugs together were more likely to experience drug-induced long QT syndrome (LQTS), a potentially fatal condition, than those who received either drug alone."
Study highlights drug-drug interaction risk from two commonly used drugs, October 12, 2016, Continue Reading
"Investigators at Columbia University discovered that adverse event reports and electronic health records, along with targeted tests, were effective in confirming the challenging-to-predict interactions - pinpointing the peril of one specific combination therapy."
Data mining, lab testing approach reveals ceftriaxone-lansoprazole interaction, October 20, 2016, Continue Reading
Predicting G protein-coupled receptor downstream signaling by tissue expression Bioinformatics July 2016
Yun Hao and Nicholas P. Tatonetti
A novel, rapid method to compare the therapeutic windows of oral anticoagulants using the Hill coefficient Scientific Reports July 2016
Jeremy B Chang, Kayla M Quinnies, Ron Realubit, Charles Karan, Jacob H Rand, Nicholas P Tatonetti
Investigation of 7-dehydrocholesterol reductase pathway to elucidate off-target prenatal effects of pharmaceuticals: a systematic review The Pharmacogenomics Journal July 2016
Mary Regina Boland, Nicholas P Tatonetti
Prognosis of Clinical Outcomes with Temporal Patterns and Experiences with One Class Feature Selection IEEE/ACM Transactions on Computational Biology and Bioinformatics July 2016
Robert Moskovitch, Hyunmi Choi, George Hripcsak, Nicholas P Tatonetti
An Integrative Data Science Pipeline to Identify Novel Drug Interactions that Prolong the QT Interval Drug Safety February 2016
Tal Lorberbaum, Kevin J. Sampson, Raymond L. Woosley, Robert S. Kass, Nicholas P. Tatonetti
"The experiment began with thousands of patient files, millions of prescription orders, billions of clinical measurements and a single question: Could big data be used to discover deadly drug combinations?"
Hunt for dangerous drug interactions reveals strategy that can save lives, February 11, 2016, Continue Reading
Mapping the effects of drugs on the immune system Nature Biotechnology November 2015
BA Kidd, A Wroblewska, Mary R Boland, J Agudo, M Merad, Nicholas P Tatonetti, BD Brown, JT Dudley
VenomKB, a new knowledge base for facilitating the validation of putative venom therapies Scientific Data November 2015
Joseph D Romano, Nicholas P Tatonetti
"The bite of a poisonous snake, scorpion or other venomous creature could very well kill you, but it also might be able to heal certain medical conditions like cancer, diabetes and heart failure"
Animal Venom Database Could Be Boon To Drug Development , November 29, 2015, Continue Reading
"Sometimes what should hurt you, helps you, and what sounds like folklore turns out to be really science. The saliva of the Gila Monster, an orange speckled lizard native to the American Southwest, is poisonous - but it also can be used to effectively treat Type 2 diabetes..."
VenomKB, a Therapeutic Natural Toxins Database, Makes Folklore Into Science , December 8, 2015, Continue Reading
Connectivity Homology Enables Inter-Species Network Models of Synthetic Lethality PLOS Computational Biology October 2015
Alexandra Jacunski, Scott Dixon, Nicholas P Tatonetti
Birth Month Affects Lifetime Disease Risk: A Phenome-Wide Method. Journal of the American Medical Informatics Association June 2015
Mary Regina Boland, Zachary Shahn, David Madigan, George Hripcsak, Nicholas P Tatonetti
"By delving into the extensive database of patients seen at Columbia Medical Center over 14 years, beginning in 2000, Tatonetti and his team did a first-of-its kind look at whether birth month has anything to do with disease risk."
See What Diseases You're at Risk For Based on Your Birth Month, June 8, 2015, Continue Reading
"Mary Regina Boland, Nicholas Tatonetti and other researchers at the Columbia University Department of Medicine examined records for an incredible 1.75 million patients born between 1900 and 2000 who had been treated at Columbia University Medical Center. Using statistical analysis, they combed through 1,688 different diseases and found 55 that had a correlation with birth month."
Scientists have discovered how the month you're born matters for your health, June 15, 2015, Continue Reading
"The Columbia researchers also found that one in 675 occurrences of ADHD (attention deficit hyperactivity disorder) could relate to being born in New York in November, which matches a Swedish study showing the highest rates of ADHD in November babies."
Could your birth month indicate your risk of disease?, June 9, 2015, Continue Reading
"The results of this study should be interpreted carefully, researchers said. For one, the study only examined data collected from one hospital in New York City; therefore, health data may be skewed due to New York's climate. Furthermore, sick patients tend to be overrepresented in electronic health records, because, well, they are visiting the doctor more often."
Your Birth Month Influences Your Risk for Diseases, June 9, 2015, Continue Reading
"Columbia University scientists compiled the birthdays and medical records of patients from New York City databases and found that people with May birthdays may have the healthiest outcomes, while people born in October might be at the highest risk for certain diseases."
Birth month may correlate to some diseases (bad news, October), June 8, 2015, Continue Reading
[VIDEO] "Some people swear by the predictive powers of zodiac signs. And while there's no scientific evidence to support Capricorns having better luck with Scorpios, this guy says the month you're born in could make a difference in your future health."
The study says there are at least 55 diseases that are significantly dependent on birth month., June 10, 2015, Watch the Video
Systems Pharmacology Augments Drug Safety Surveillance. Clinical Pharmacology & Therapeutics February 2015
Tal Lorberbaum, Mavra Nasir, Michael J Keiser, Santiago Vilar, George Hripcsak, Nicholas P Tatonetti
Similarity-based modeling in large-scale prediction of drug-drug interactions. Nature Protocols August 14, 2014
Santiago Vilar, Eugenio Uriarte, Lourdes Santana, Tal Lorberbaum, George Hripcsak, Carol Friedman, Nicholas P Tatonetti
Disease Risk Factors Identified Through Shared Genetic Architecture and Electronic Medical Records. Science Translational Medicine April 30, 2014
Li Li, David J Ruau, Chirag J Patel, Susan C Weber, Rong Chen, Nicholas P Tatonetti, Joel T Dudley, and Atul J Butte
By NIH Director Dr. Francis Collins, "Biomedical researchers and clinicians are generating an enormous, ever-expanding trove of digital data: through DNA sequencing, biomedical imaging, and by replacing a patient's medical chart with a lifelong electronic medical record. What can be done with all of this 'Big Data'?"
Mining the Big Data Mountain, May 6, 2014, source
The Weber Effect and the United States Food and Drug Administration's Adverse Event Reporting System (FAERS): Analysis of Sixty-Two Drugs Approved from 2006 to 2010. Drug Safety April 4, 2014
Keith B Hoffman, Mo Dimbil, Colin B Erdman, Nicholas P Tatonetti, and Brian M Overstreet
Coherent Functional Modules Improve Transcription Factor Target Identification, Cooperativity Prediction, and Disease Association. PLOS Genetics February 6, 2014
Konrad J. Karczewski, Michael Snyder, Russ B. Altman, and Nicholas P. Tatonetti
Connecting the Dots: Applications of Network Medicine in Pharmacology and Disease. Clinical Pharmacology and Therapeutics October 10, 2013
Alexandra Jacunski and Nicholas P. Tatonetti.
High-Throughput Methods for Combinatorial Drug Discovery. Science Translational Medicine October 2, 2013
Xiaochen Sun, Santiago Vilar, and Nicholas P. Tatonetti.
Web-scale pharmacovigilance: listening to signals from the crowd. Journal of the American Medical Informatics Association March 6, 2013
Ryen W White, Nicholas P. Tatonetti, Nigam H. Shah, Russ B. Altman, and Eric Horvitz.
Listen to Dr. Eric Horvitz discuss our work with Ira Flatow on NPR's Science Friday.
Improving Healthcare, One Search at a Time, March 15, 2013, source

"...the Stanford and Columbia University joint research team sifted though 6 million users' internet search queries (which you'll be uncomfortable to know, are forever saved in web search logs) and looked for searches that related to the antidepressant paroxetine and the cholesterol-lowering drug pravastatin."
Your Google Searches Can Uncover Drug Side Effects Faster Than the FDA, March 6, 2013, source
"Much like Google Flu Trends reveals influenza outbreaks by tracking flu-related search terms, search queries about drug combinations and possible side effects-say, "paroxetine," "pravastatin," and "hyperglycemia"-might enable researchers to identify unanticipated downsides."
Should You Mix Those Two Drugs? Ask Dr. Google, March 6, 2013, source
"Using automated software tools to examine queries by six million Internet users taken from Web search logs in 2010, the researchers looked for searches relating to an antidepressant, paroxetine, and a cholesterol lowering drug, pravastatin. They were able to find evidence that the combination of the two drugs caused high blood sugar."
Unreported Side Effects of Drugs Are Found Using Internet Search Data, Study Finds, March 6, 2013, source
Data-driven prediction of drug effects and interactions. Science Translational Medicine 4, 125ra31 (2012).
Nicholas P Tatonetti, et al.
"An algorithm designed by US scientists to trawl through a plethora of drug interactions has yielded thousands of previously unknown side effects caused by taking drugs in combination"
Drug data reveal sneaky side effects, March 14, 2012, source
"... researchers have shown thousands of previously unknown side effects caused when some drugs are taken in combination ..."
Good Apart, Bad Together, March 15, 2012, source
"There's always that part at the end of drug commercials that goes something like: if you develop sausage fingers, webbed feet, or a three-week erection, call your doctor! But as exhaustive as those auctioneer-style lists sound, they barely scratch the surface when it comes to the side effects people are actually experiencing."
Drugs Cause About Five Times More Side Effects Than We Realized, March 15, 2012, source
"It's a funny thing about clinical trials: they're set up so that all the subjects taking the drug in question are totally healthy in every other respect and on no other medications. It's the only way to see if the drug has an effect, but as soon as people start taking it in the real world, well... let's just say that most patients don't measure up to the pristine condition of clinical subjects."
Analysis of Drug Database Reveals Thousands of Potentially Dangerous Interactions, March 15, 2012, source
"Un grupo de investigadores ha disenado metodos computacionales para predecir las interacciones entre medicamentos y sus consecuencias adversas ..."
Predicen con algoritmos los efectos secundarios de mezclar farmacos, March 15, 2012, source
A novel signal detection algorithm for identifying hidden drug-drug interactions in adverse event reports. J Am Med Inform Assoc (2011)
Nicholas P Tatonetti, et al.
Detecting Drug Interactions From Adverse-Event Reports: Interaction Between Paroxetine and Pravastatin Increases Blood Glucose Levels Clinical Pharmacology & Therapeutics (2011)
Nicholas P Tatonetti, et al.
"Dr. Tatonetti devised an algorithm to look for pairs of drugs that, taken together, cause a side effect not associated with either drug alone. One pairing popped up when he used his new software to search the Food and Drug Administration's database of adverse drug reports: Paxil, a widely used antidepressant, and Pravastatin, a cholesterol-lowering drug. ..."
Mining Electronic Records for Revealing Health Data, January 14, 2013, source
"Up to 1 million patients in the United States may be taking 2 medications that can lead to unexpected increases in blood glucose levels when used simultaneously. Data mining techniques have revealed that the combination of the antidepressant paroxetine and the cholesterol-lowering medication pravastatin may cause this adverse effect ..."
Data Mining Approach Shows Promise in Detecting Unexpected Drug Interactions, July 13, 2011, source
"Researchers mined FDA's Adverse Event Reporting System (AERS) for reports of side effects involving glucose homeostasis."
Data-mining uncovers hyperglycemic drug-drug interaction between paroxetine and pravastatin, August 15, 2011, source
"Americans have been led to believe -- by their doctors, by advertisers and by the pharmaceutical industry -- that there is a pill to cure just about anything that ails them."
Are you taking too many meds?, May 31, 2011, source
"The side effect ... was unexpected, and its discovery illustrates the power of electronic health records to help bring to light previously unknown problems with medical treatments."
Study warns on use of 2 common drugs, May 28, 2011, source
"[By] combin[ing] a list of drugs known to affect pathways involved in diabetes, and then mined AERS for side effects associated with these drugs. Then they set their algorithms loose on AERS to find combinations of drugs that produced the same constellation of side effects, thinking that these might also affect pathways involved in diabetes."
Common drug combo increases diabetes risk, May, 2011, source
Interpretome: A freely available, modular, and secure personal genome interpretation engine. Pac Symp Biocomput 17:339-350(2012)
Konrad Karczewski, Rob Tirrell, Pablo Cordero, Nicholas P Tatonetti, et al.
"a very handy set of online tools for analysing personal genomic data. The tools work within your browser, meaning your genetic data never actually leaves your computer."
Interpretome: new online tools for analysing personal genome data, June 14, 2011, source
Cooperative transcription factor associations discovered using regulatory variation. Proceedings of the National Academy of Science USA 108, 13353-13358 (2011).
Konrad Karczewski, Nicholas P Tatonetti, et al.
Predicting drug side-effects by chemical systems biology. Genome Biology (2009) vol. 10 (9) pp. 238
Tatonetti NP, Liu T, Altman RB.