Detecting Drug Interactions From Adverse-Event Reports: Interaction Between Paroxetine and Pravastatin Increases Blood Glucose Levels

“Dr. Tatonetti devised an algorithm to look for pairs of drugs that, taken together, cause a side effect not associated with either drug alone. One pairing popped up when he used his new software to search the Food and Drug Administration’s database of adverse drug reports: Paxil, a widely used antidepressant, and Pravastatin, a cholesterol-lowering drug. …”
Mining Electronic Records for Revealing Health Data, January 14, 2013, source

“Up to 1 million patients in the United States may be taking 2 medications that can lead to unexpected increases in blood glucose levels when used simultaneously. Data mining techniques have revealed that the combination of the antidepressant paroxetine and the cholesterol-lowering medication pravastatin may cause this adverse effect …”
Data Mining Approach Shows Promise in Detecting Unexpected Drug Interactions, July 13, 2011, source

“Researchers mined FDA’s Adverse Event Reporting System (AERS) for reports of side effects involving glucose homeostasis.”
Data-mining uncovers hyperglycemic drug-drug interaction between paroxetine and pravastatin, August 15, 2011, source

“Americans have been led to believe — by their doctors, by advertisers and by the pharmaceutical industry — that there is a pill to cure just about anything that ails them.”
Are you taking too many meds?, May 31, 2011, source

“The side effect … was unexpected, and its discovery illustrates the power of electronic health records to help bring to light previously unknown problems with medical treatments.”
Study warns on use of 2 common drugs, May 28, 2011, source

“[By] combin[ing] a list of drugs known to affect pathways involved in diabetes, and then mined AERS for side effects associated with these drugs. Then they set their algorithms loose on AERS to find combinations of drugs that produced the same constellation of side effects, thinking that these might also affect pathways involved in diabetes.”
Common drug combo increases diabetes risk, May, 2011, source